Flemish researchers launch OPENPichia, an industrial open access yeast system for the production of proteins

Hi All

Here is a really nice project from Katrien Claes, Nico Callewaert and team at VIB-UGent Center for Medical Biotechnology :clap:

A team of researchers at the VIB-UGent Center for Medical Biotechnology has succeeded in reconstructing one of the most important industrial expression systems for proteins in open access. Pichia pastoris, a yeast used in the biopharmaceutical industry is often used to produce molecular building blocks. Up until now, use of this technology was restricted by a paywall. Thanks to this research, a similar expression system can be offered at a much lower cost. Additionally, results of new research using this open access system can be shared more easily. The results of this research have been published in Nature Microbiology.

Claes K, Van Herpe D, Vanluchene R, Roels C, Van Moer B, Wyseure E, Vandewalle K, Eeckhaut H, Yilmaz S, Vanmarcke S, Çıtak E, Fijalkowska D, Grootaert H, Lonigro C, Meuris L, Michielsen G, Naessens J, van Schie L, De Rycke R, De Bruyne M, Borghgraef P, and Callewaert N. OPENPichia: licence-free Komagataella phaffii chassis strains and toolkit for protein expression. Nat microb (2024) doi: 10.1038/s41564-023-01574-w

https://www.nature.com/articles/s41564-023-01574-w